Flexeril: Uses, Side Effects, Precautions, and some common FAQs

Older adults may be more sensitive to the effects of this medicine. It may not be safe to breast-feed while using this medicine. Do not use cyclobenzaprine if you have taken an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, or tranylcypromine. Flexeril may also be used for purposes not listed in this medication guide. If you are not able to swallow the extended-release capsule whole, mix the contents of the capsule with applesauce.

The efficacy of FLEXERIL 5 mg was demonstrated in two seven-day, double-blind, controlled clinical trials enrolling 1405 patients. One study compared FLEXERIL 5 mg and 10 mg t.i.d. to placebo; and a second study compared FLEXERIL 5 mg and 2.5 mg t.i.d. to placebo. Primary endpoints for both trials were determined by patient-generated data and included global impression of change, medication helpfulness, flexeril and promethazine and relief from starting backache. Each endpoint consisted of a score on a 5-point rating scale (from 0 or worst outcome to 4 or best outcome). Eight double-blind controlled clinical studies were performed in 642 patients comparing FLEXERIL 10 mg, diazepam, and placebo. Muscle spasm, local pain and tenderness, limitation of motion, and restriction in activities of daily living were evaluated.

• However, your physician can better decide which drug is better for your back pain.
• Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking.
• Also, many of the medicines used to treat fibromyalgia work by boosting the amount of serotonin in your body.
• Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases.

In the US – Call your doctor for medical advice about side effects. You may report side effects to FDA at FDA-1088 or at /medwatch. Cyclobenzaprine is available as immediate- and extended-release tablets and capsules.

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Cyclobenzaprine acts on the central nervous system (CNS) to produce its muscle relaxant effects. Its actions on the CNS may also cause some of this medicine’s side effects. Antispastic medications are effective in treating spasticity, but high doses can lead to unwanted side effects. Other treatments can help with spasticity as well, including physical therapy and Botox® injections. This article focuses on skeletal muscle relaxants, as opposed to smooth muscle relaxants.

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Ell your doctor if your condition lasts after 2 to 3 weeks or if it gets worse. If additional types of substance dependence (e.g., alcohol, opioids, sedatives) are a factor, medical detox may be needed. The presence of discontinuation symptoms alone is not indicative of addiction.

A Flexeril overdose can cause severe health problems such as cardiac arrest, dangerously low blood pressure, and seizures. Central nervous system depression, seizures, heart attack, and even death can occur. Our goal is to provide you with the most relevant and current information.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines.

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Muscle relaxers have a potential for misuse and addiction, especially carisoprodol and diazepam. Prolonged use can lead to increased tolerance and physical dependence. Spasticity is a disruption in muscle movement patterns that causes certain muscles to contract all at once when you try to move or even at rest. It’s usually caused by damage to nerve pathways within your brain or spinal cord that control movement and stretch reflexes. Keep this and all medicines out of the reach of children.

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Do not drive or operate machinery until you know howFlexeril affects you. Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication. Ask your doctor when to start or stop taking this medication.

Pain Amplification Syndromes

Flexeril is considered safe enough to not be classified as a controlled substance or a narcotic. Flexeril is not considered a controlled substance or narcotic by the U.S. If you have symptoms of overdose, call 911 or go to the nearest emergency room.